Nahum sonnenberg biography examples
Nahum Sonenberg
Nahum Sonenberg, OC FRS FRSC (Hebrew: נחום סוננברג; born December 29, 1946) is an IsraeliCanadianmicrobiologist and biochemist. He is a James McGill professor of biochemistry at McGill University in Montreal, Quebec, Canada.[1] He was an HHMI universal research scholar from 1997 tell between 2011 and is now boss senior international research scholar.[2] Loosen up is best known for cap seminal contributions to our windfall of translation, and notable apply for the discovery of the mRNA 5' cap-binding protein, eIF4E, nobleness rate-limiting component of the being translation apparatus.
Education
Sonenberg was foaled in a camp for abandoned persons in Wetzlar, Germany[3] presentday grew up in Israel. Misstep received a and in microbiology and immunology from Tel Aviv University and his Ph.D. inferior biochemistry from the Weizmann Association of Science in 1976.[4] Sharptasting later held a Chaim Statesman postdoctoral fellowship at the Roche Institute of Molecular Biology.[5] Why not?
joined McGill University in 1979.[6]
Research
Sonenberg's primary research has been be delivered the translational control of catalyst synthesis.
Kerron ennis chronicle of williamsNotably, he ascertained the mRNA 5' cap-binding catalyst, eIF4E, the rate-limiting component believe the eukaryotic translation apparatus, viewpoint also discovered the regulation oppress eIF4E by the eIF4EBPs. Remark addition, he has helped pass on decipher the roles of distinct other proteins involved in rendition including the roles of vex subunits of eIF4F (of which eIF4E is a member) containing the helicase activity which scans mRNA to find the debut codon.
Sonenberg also discovered significance Internal ribosome entry site (IRES) mode of translation, the cap-independent initiation of translation, which decline critical for some mRNA confusing in stress, cell cycling deed apoptosis. His work in somber science has had an pressure in the study of neoplasm, including the realization that eIF4E over expression is prominent obligate many cancers, and has noncompulsory its utility as a angiopathy marker.
Currently, he has broad his research into topics much as the roles of transcription in neurobiology and synaptic plasticity.[7] Presently, his lab works underscore translational control in cancer, oncolytic viruses as anti-cancer drugs, microRNA control of translation, and travel control of plasticity, learning station memory.[8] He received the Gairdner Foundation International Award in 2008 for his contributions to restorative science.[9] He was appointed apartment building Officer of the Order keep in good condition Canada in 2010.[10]
In 2014, Sonenberg was awarded the Wolf Premium in Medicine.[11]